Cart
sales@molnova.com
Home - Products - Cell Cycle/DNA Damage - ROCK - Cucurbitacin A

Cucurbitacin A

CAS No. 6040-19-3

Cucurbitacin A( —— )

Catalog No. M21905 CAS No. 6040-19-3

Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/ROCK pathway and inhibition of LIM-Kinase.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 360 Get Quote
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Cucurbitacin A
  • Note
    Research use only, not for human use.
  • Brief Description
    Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/ROCK pathway and inhibition of LIM-Kinase.
  • Description
    Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/ROCK pathway and inhibition of LIM-Kinase.
  • In Vitro
    Cucurbitacin A inhibits the proliferation of A549 and BEL-7402 cells with IC50 values of 0.4 and 0.3 μM, respectively.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    ROCK
  • Recptor
    ROCK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    6040-19-3
  • Formula Weight
    574.7
  • Molecular Formula
    C32H46O9
  • Purity
    >98% (HPLC)
  • Solubility
    Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
  • SMILES
    CC(=O)OC(C)(C)C=CC(=O)C(C)(C1C(CC2(C1(CC(=O)C3(C2CC=C4C3CC(C(=O)C4(C)C)O)CO)C)C)O)O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Cucurbitacin I elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/ROCK pathway and inhibition of LIM-kinase.Biochem. Pharmacol., 2015, 102:45-63.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • (1R,2S)-VU0155041

    (1R,2S)-VU0155041 is a partial agonist of mGluR4(EC50 of 2.35 μM).

  • NSC 409012

    NSC 409012 is an active compound.

  • RKI-1447

    RKI-1447 is a potent inhibitor of ROCK1 and ROCK2, with IC50 of 14.5 nM and 6.2 nM, respectively, has anti-invasive and antitumor activities.

Sign In Join Free